Some of the poker tournament strategy that is adopted can turn one to an underdog to any kind of hand that an opponent can hold.  This can possibly be true with calling hands like A-10 where the rest of the table folds in a no limit holdem and the opponent have been making all the raises from under the gun. This is the time when one must rather decide to fold than risk some more stakes making the play worse than ever. Out of position hands should be folded despite all the huge stakes that has already been invested, the least that one can do is to prevent any further loss.